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    常州市存仁生物工程有限公司

    產品 > Aurora/Ksp > Aurora > AMG900
    產品名稱 : AMG900
    型號 : CR1029
    CAS : 945595-80-2
    備注:所有產品僅用作科學研究,我們不為任何個人用途提供產品和服務 : 
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    產品詳細:

    Description of:AMG 900
    AMG 900 repressed autophosphorylation of aurorakinases A and B as well as the phosphorylation of histone H3.The predominant cellular response of tumor cells to AMG 900treatment is aborted cell division without a mitotic arrest, which leads to endoreduplication and cell death. AMG 900 suppressed the proliferation of tumor cell lines at low nanomolar concentrations (EC50 values 1–6nM). Importantly, AMG 900 was equally potent against multidrugresistant(MDR) cell lines expressing ATP-binding cassette transporters(P-gp and BCRP1). However, paclitaxel and three aurora kinase inhibitors (AZD1152, MK-0457, and PHA-739358) indicated ed a loss of potency in these MDR-positive cell lines compared with matched parental cell lines. AMG 900 induced an accumulation of cells with 4N DNA content (EC50 value 5 nM) and prevented colony formation in this AZD1152-resistant HCT116 subline. [1] AMG 900 was rapidly metabolized in liver microsomes and highly bound to plasma proteins in the species tested. AMG 900 was a weak Pgp substrate with good passive permeability.


    Theoretical analysis:AMG900
    M.Wt: 503.58
    Formula: C28H21N7OS
    Solubility: Unknown
    Purity: >99%
    Storage: at -20℃ 2 years
    CAS No: 945595-80-2

    Availability and price:
    Pakage:200mg/500mg/1g/2g
    We offer significant discount for larger quantity order.
    For quotation, question, and order, please send email to : 
    sales@chemrenpharm.com
    Quality control data:
    Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
    Product will be shipped with supporting analytical data.
    Fast delivery about 4-5 working days

     


     


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